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HRBR Automatic Multi-Plate Bioreactor (AMPBR) System

​The AMPBR is based on our HRBR technology for adherent cell cultures using 2D multi-tray culture vessel. The novel automatic multi-plate bioreactor (AMPBR) system is similar to our automatic multi-tray bioreactor (AMTBR) system except the vessel comprising a single closed vessel filled with a module of multiple plates.   AMTBR comprises multiple trays stacked together and forms multiple compartments communicated with common manifolds. AMPBR has only one compartment. The oxygenation of this system relies primarily on the performance of Roller Bottle Principle.

How Does It Work?

​•    Use of HRBR technology and a supporting container which holds the multi-plate vessel to serve as an incubator. Also performs all culture processes in one closed system
•    Application of active gassing to promote the gas exchange in the gas phase.
•    Performance of the roller bottle principle for the most efficient oxygenation.

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The below tables illustrates the major differences between the AMTBR and the AMCF.

System Features

Conventional

multi-layer

40 tray vessel

Cell Factory or

Cellstack

Conventional

multi-layer

40 tray vessel

Cell Factory, with

AMCF system

(auto-manipulator)

Conventional

multi-layer

40 tray

vessel

Cell Factory, with

AMTBR1

Modified multi-tray vessel I

with

AMTBR1

Modified multi-tray vessel II

(w/o turncock)

with

AMTBR2

Modified multi-tray vessel II

(w turncock)

with

AMTBR2

Operation

All manual

Semi-automated

Total automation

Total automation

Total automation

Total automation

Controllability

Minimal

Minimal

Maximum

Maximum

Maximum

Maximum

Vessel Size for Equiv. Surface Area (25,280cm3/vessel)

47.5

47.5

47.5

15.84

15.84

7.92

Capital Cost

$100k

$700k+

Less than

$100k

Less than

$80k

Less than

$70k

Less than

$50k

Labor Intensive?

Yes

Yes

No

No

No

No

Closed System?

No

No

Yes

Yes

Yes

Yes

Gassing

Passive

Passive

Active

Active

Active

Active

Platform

n/a

n/a

See-saw

See-saw

Fixed

Fixed

Rotating Action

3D

3D

3D

3D

2D

2D

Culture Method

Static

Static

Static

Static

Static

Dynamic

Function

Limited

static culture only

Limited

static culture only

Unlimited

bioreactor

function

Unlimited

bioreactor

function

Unlimited

bioreactor

function

Unlimited

bioreactor

function

Separate             CO2 Incubator?

Yes

Yes

No

No

No

No

Seeding

Manual

Semi-Auto

Auto

Auto

Auto

Auto

Medium Exchange

(Filling/Emptying)

Manual

Semi-Auto

Auto

Auto

Auto

Auto

Infection / Transfection

Manual

Semi-Auto

Auto

Auto

Auto

Auto

Cell Detachment

Manual

Semi-Auto

Auto

Auto

Auto

Auto

Sampling

Manual

Manual

Auto

Auto

Auto

Auto

Harvesting

Manual

Semi-Auto

Auto

Auto

Auto

Auto

 

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Model No.

Description

Vessel Type

No. of Trays

No. of Vessels

HRBR130

Automatic Multi-Tray Bioreactor 1 (AMTBR1)

Cell Factory*

2, 4, 10, & 40

1,2,4

MTV1**

n/a

1,2,4

HRBR131

Automatic Multi-tray Bioreactor 2 (AMBR2)

MTV2**

n/a

1,2,4

*or the equivalent i.e. Cellstack                                                                  ** not available at this time

 

The size of the AMTBR 1 & 2 is dependent on the type of vessel, the number of trays & vessels.

 

 

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BioReactor Sciences  |  1150 Home Place Drive  |  Lawrenceville, GA 30043  |  678-243-0920  |  info@bioreactorsciences.com